The Kansas City Chiefs will aim to remain undefeated on Sunday as they take on the San Francisco 49ers. Although the Chiefs are coming off their bye in Week 6 without any losses, they have faced significant health challenges on offense. Their receiving corps has particularly struggled, with Rashee Rice and Marquise Brown both ruled out for the season. Nevertheless, Kansas City had its best offensive outing of the year in Week 5, amassing 460 yards and seeing Patrick Mahomes throw for a season-high 321 yards. However, they may be without another key player this Sunday, as JuJu Smith-Schuster was added to the injury report with a hamstring issue on Thursday.
It remains uncertain whether Smith-Schuster will be able to play on Sunday, as midweek injuries often signal trouble for upcoming games. The Chiefs’ injury report on Friday will likely provide a clearer picture of his availability against the Titans. If Smith-Schuster cannot play, it would be a significant blow for the Chiefs, as he led the team in their Week 5 victory with seven receptions for 130 yards. Without him, Kansas City will need to lean on tight end Travis Kelce and rookie Xavier Worthy to face a tough 49ers defense, and running back Kareem Hunt may also see an increased workload.